Lytic cycle: A defining process in oncolytic virotherapy
نویسندگان
چکیده
منابع مشابه
The replicability of oncolytic virus: defining conditions in tumor virotherapy.
The replicability of an oncolytic virus is measured by its burst size. The burst size is the number of new viruses coming out from a lysis of an infected tumor cell. Some clinical evidences show that the burst size of an oncolytic virus is a defining parameter for the success of virotherapy. This article analyzes a basic mathematical model that includes burst size for oncolytic virotherapy. The...
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PURPOSE Recent data from randomized clinical trials with oncolytic viral therapies and with cancer immunotherapies have finally recapitulated the promise these platforms demonstrated in preclinical models. Perhaps the greatest advance with oncolytic virotherapy has been the appreciation of the importance of activation of the immune response in therapeutic activity. Meanwhile, the understanding ...
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ژورنال
عنوان ژورنال: Applied Mathematical Modelling
سال: 2013
ISSN: 0307-904X
DOI: 10.1016/j.apm.2012.12.004